Mastocytosis
| Mastocytosis | |
|---|---|
| Other names | Clonal bone marrow disorder |
| Micrograph of mastocytosis. Skin biopsy. H&E stain. | |
| Specialty | Clinical Immunology and Allergy, Oncology, hematology |
Mastocytosis, a type of mast cell disease, is a rare disorder affecting both children and adults caused by the accumulation of functionally defective mast cells (also called mastocytes) and CD34+ mast cell precursors.
People affected by mastocytosis are susceptible to a variety of symptoms, including itching, hives, and anaphylactic shock, caused by the release of histamine and other pro-inflammatory substances from mast cells.