Melanin-concentrating hormone receptor 1

MCHR1
Identifiers
Aliases	MCHR1, GPR24, MCH-1R, MCH1R, SLC-1, SLC1, melanin concentrating hormone receptor 1
External IDs	OMIM: 601751; MGI: 2180756; HomoloGene: 21097; GeneCards: MCHR1; OMA:MCHR1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	40,682,812 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,123,165 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; prefrontal cortex; ; superior frontal gyrus; ; entorhinal cortex; ; postcentral gyrus; ; primary visual cortex; ; dorsolateral prefrontal cortex; ; cingulate gyrus;
	Top expressed in
	lumbar subsegment of spinal cord; ; Paneth cell; ; superior frontal gyrus; ; Region I of hippocampus proper; ; facial motor nucleus; ; primary visual cortex; ; substantia nigra; ; dentate gyrus of hippocampal formation granule cell; ; nucleus accumbens; ; dorsal striatum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; melanin-concentrating hormone receptor activity; neuropeptide receptor activity; signaling receptor binding; protein C-terminus binding; hormone binding; neuropeptide binding; peptide binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; ciliary membrane; non-motile cilium; cilium;
Biological process	G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; generation of precursor metabolites and energy; feeding behavior; signal transduction; chemical synaptic transmission; cell surface receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of calcium ion transport;
	Sources:Amigo / QuickGO
Orthologs
	2847
	207911
	ENSG00000128285
	ENSMUSG00000050164
	Q99705
	Q8JZL2
	NM_005297
	NM_145132
	NP_005288
	NP_660114
	Wikidata
View/Edit Human	View/Edit Mouse

Melanin-concentrating hormone receptor 1, also known as MCH₁, is one of the melanin-concentrating hormone receptors found in all mammals.

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.