Melanotransferrin

MELTF
Identifiers
Aliases	MELTF, CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDs	OMIM: 155750; MGI: 1353421; HomoloGene: 4335; GeneCards: MELTF; OMA:MELTF - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	197,029,835 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	31,717,838 bp
RNA expression pattern
	Top expressed in
	tibia; ; parotid gland; ; decidua; ; tendon of biceps brachii; ; renal medulla; ; parietal pleura; ; cartilage tissue; ; endothelial cell; ; amniotic fluid; ; germinal epithelium;
	Top expressed in
	vestibular sensory epithelium; ; stria vascularis; ; epithelium of small intestine; ; trachea; ; migratory enteric neural crest cell; ; utricle; ; vestibular membrane of cochlear duct; ; intercostal muscle; ; ankle joint; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; protein binding; metal ion binding;
Cellular component	cell surface; anchored component of plasma membrane; anchored component of membrane; integral component of plasma membrane; extracellular exosome; membrane; extracellular region; extracellular space; plasma membrane; endoplasmic reticulum lumen;
Biological process	positive regulation of extracellular matrix disassembly; iron ion homeostasis; negative regulation of substrate adhesion-dependent cell spreading; regulation of cell population proliferation; positive regulation of plasminogen activation; ion transport; regulation of cell growth; C-terminal protein lipidation; post-translational protein modification; transport; iron ion transport;
	Sources:Amigo / QuickGO
Orthologs
	4241
	30060
	ENSG00000163975
	ENSMUSG00000022780
	P08582
	Q9R0R1
	NM_005929; NM_033316
	NM_013900
	NP_005920; NP_201573
	NP_038928
	Wikidata
View/Edit Human	View/Edit Mouse

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.