Metal transporter CNNM3

Metal transporter CNNM3 (also known as cyclin M3 or Ancient conserved domain-containing protein 3) is a human transmembrane protein which is made up of 707 amino acids. Although CNNM3 is ubiquitous, it is mostly present in the kidney, brain, lung, spleen, heart and liver.

When was discovered, CNNM3 protein was called cyclin M3 because of the similarity on its sequence with the cyclin family. However, it belongs to CNNMs transmembrane family, together with CNNM1, CNNM2 and CNNM4. The main function of CNNM3, along with the other CNNM proteins, is to regulate Mg2+ levels in the cell and maintain its homeostasis. Moreover, it is codified by the gene CNNM3 or ACDP3.