3,4-Methylenedioxyamphetamine
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| Other names | MDA; Tenamfetamine; Amphedoxamine; Sally; Sassafras; Sass-a-frass; Sass; Mellow Drug of America; Hug drug; Love; 3,4-Methylenedioxy-α-methylphenethylamine; 5-(2-Aminopropyl)-1,3-benzodioxole; EA-1298; NSC-9978; NSC-27106; SKF-5 |
| Routes of administration | By mouth, sublingual, insufflation, intravenous |
| Drug class | Entactogen; Stimulant; Psychedelic; Serotonin–norepinephrine–dopamine releasing agent; Serotonin 5-HT2 receptor agonist |
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| Pharmacokinetic data | |
| Metabolism | Hepatic (CYP extensively involved) |
| Elimination half-life | 10.9 hours |
| Duration of action | 6–8 hours |
| Excretion | Renal |
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| ECHA InfoCard | 100.230.706 |
| Chemical and physical data | |
| Formula | C10H13NO2 |
| Molar mass | 179.219 g·mol−1 |
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3,4-Methylenedioxyamphetamine (MDA) is an entactogen, stimulant, and psychedelic drug of the amphetamine and MDxx families that is encountered mainly as a recreational drug. In its pharmacology, MDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA). In most countries, the drug is a controlled substance and its possession and sale are illegal.
MDA is rarely sought as a recreational drug compared to other amphetamines; however, it remains widely used due to it being a primary metabolite, the product of hepatic N-dealkylation, of MDMA. It is also a common adulterant of illicitly produced MDMA.