Mexicana de Aviación (1921–2010)

Mexicana de Aviación
	Mexicana de Aviación Tower, the former worldwide headquarters of the airline in 2009
Founded	July 12, 1921
Commenced operations	August 30, 1921
Ceased operations	August 28, 2010
Hubs	Cancún; Guadalajara; Mexico City–Benito Juárez;
Focus cities	Chicago–O'Hare; Los Angeles; Morelia; Tijuana; Zacatecas;
Frequent-flyer program	Mexicana Go
Alliance	Star Alliance (2000–2004); Oneworld (2009–2010);
Subsidiaries	Aerocaribe (1972–2005); AeroCozumel (1978–2002); Aeromonterrey (1991–1995); Mexicana Cargo (1980–1987); MexicanaClick (2005–2010); MexicanaLink (2009–2010);
Parent company	SEDENA
Headquarters	Mexicana de Aviación Tower, Mexico City, Ciudad de Mexico, Mexico
Key people	Gerardo Badin (Conciliator/Administrator)
Website	www.mexicana.gob.mx

Compañía Mexicana de Aviación S.A. de C.V., usually shortened to Mexicana de Aviación, was Mexico's oldest airline and one of the oldest continuously single-branded airlines, inaugurated in 1921. It was Mexico's biggest airline and flag carrier before ceasing operations on August 28, 2010, leaving competitor Aeroméxico as a de facto monopoly.

A revival airline is operated by SEDENA – the Mexican Ministry of Defense, as a state-owned airline. It began operations in December 2023 under the legal name Aerolínea del Estado Mexicano using the Mexicana brand.