Minaprine

Minaprine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	N06AX07 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); In general: ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	2-2.5 hours
Identifiers
	IUPAC name 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine;
CAS Number	25905-77-5 ;
PubChem CID	4199;
ChemSpider	4054 ;
UNII	00U7GX0NLM;
KEGG	D05039 ;
ChEMBL	ChEMBL278819 ;
CompTox Dashboard (EPA)	DTXSID5048477 ;
ECHA InfoCard	100.043.012
Chemical and physical data
Formula	C17H22N4O
Molar mass	298.390 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3;
	InChI InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20) ; Key:LDMWSLGGVTVJPG-UHFFFAOYSA-N ;

Minaprine (INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.

A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. It has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.

It has demonstrated significant antibiotic activity against M. chelonae and M. abscessus in tests with antibiotic resistant bacteria.

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	N06AX07 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances) In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life	2-2.5 hours
Identifiers
IUPAC name 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
CAS Number	25905-77-5^Y
PubChem CID	4199
ChemSpider	4054^Y
UNII	00U7GX0NLM
KEGG	D05039^Y
ChEMBL	ChEMBL278819^Y
CompTox Dashboard (EPA)	DTXSID5048477
ECHA InfoCard	100.043.012
Chemical and physical data
Formula	C₁₇H₂₂N₄O
Molar mass	298.390 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
InChI InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)^Y Key:LDMWSLGGVTVJPG-UHFFFAOYSA-N^Y