Mioflazine

Mioflazine
Clinical data
Other names	R 51469
Identifiers
	IUPAC name 1-[4,4-bis(4-fluorophenyl)butyl]-4-[2-(2,6-dichloroanilino)-2-oxoethyl]piperazine-2-carboxamide;
CAS Number	79467-23-5;
PubChem CID	72001;
ChemSpider	65001;
UNII	8YF140A099;
ChEMBL	ChEMBL2110980;
CompTox Dashboard (EPA)	DTXSID00868521 ;
Chemical and physical data
Formula	C29H30Cl2F2N4O2
Molar mass	575.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(C(CN1CC(=O)NC2=C(C=CC=C2Cl)Cl)C(=O)N)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F;
	InChI InChI=1S/C29H30Cl2F2N4O2/c30-24-4-1-5-25(31)28(24)35-27(38)18-36-15-16-37(26(17-36)29(34)39)14-2-3-23(19-6-10-21(32)11-7-19)20-8-12-22(33)13-9-20/h1,4-13,23,26H,2-3,14-18H2,(H2,34,39)(H,35,38); Key:VWXFUOAKGNJSBI-UHFFFAOYSA-N;

Mioflazine (R 51469) is a compound that has garnered attention due to its potential protective effects against myocardial ischemia. Primarily acting as a nucleoside transport inhibitor, mioflazine has been shown in preclinical studies to improve cardiac survival during ischemic episodes, modulate the dynamics of nucleoside accumulation during reperfusion, and exhibit unique pharmacological properties without significant inotropic effects.

Other members of this class include Lidoflazine, Draflazine & Soluflazine. R57974 has the same structure as mioflazine but is based on a 5,5-bis(4-fluorophenyl)pentyl] pendant sidechain.

Mioflazine is a member of diphenylbutylpiperazine class.