Missouri Route 221
MO 221 highlighted in red | ||||
| Route information | ||||
| Maintained by MoDOT | ||||
| Length | 16.317 mi (26.260 km) | |||
| Existed | c. 2010–2012–present | |||
| Major junctions | ||||
| West end | Route 21 near Pilot Knob | |||
| East end | US 67 near Farmington | |||
| Location | ||||
| Country | United States | |||
| State | Missouri | |||
| Counties | Iron, St. Francois | |||
| Highway system | ||||
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Route 221 is a 16.317-mile-long (26.260 km) east–west highway in eastern Missouri. Its western terminus is at Route 21 near Pilot Knob. Its eastern terminus is at U.S. Route 67 (US 67) near Farmington.