Trimebutine

Trimebutine
Clinical data
Trade names	Debridat, Recutin, Polybutin, others
AHFS/Drugs.com	International Drug Names
ATC code	A03AA05 (WHO) ;
Physiological data
Agonists	opioid receptors
Antagonists	mAChR, sodium channels
Pharmacokinetic data
Metabolites	nortrimebutine, N-didesmethyltrimebutine, 2-dimethylamino-2-phenylbutan-1-ol, 2-methylamino-2-phenylbutan-1-ol, 2-amino-2-phenylbutan-1-ol
Elimination half-life	2.77 h (for oral dose 200 mg)
Excretion	renal, fecal
Identifiers
	IUPAC name 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate;
CAS Number	39133-31-8 ;
PubChem CID	5573;
PubChem SID	310265016;
ChemSpider	5372 ;
UNII	QZ1OJ92E5R;
ChEBI	CHEBI:94458;
ChEMBL	ChEMBL190044 ;
CompTox Dashboard (EPA)	DTXSID4023707 ;
ECHA InfoCard	100.049.354
Chemical and physical data
Formula	C22H29NO5
Molar mass	387.476 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.1±0.1 g/cm³ g/cm3
Boiling point	457.9 °C (856.2 °F) at 760 mmHg
	SMILES CCC(COC(=O)C1=CC(=C(C(=C1)OC)OC)OC)(C2=CC=CC=C2)N(C)C;
	InChI InChI=1S/C22H29NO5/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5/h8-14H,7,15H2,1-6H3 ; Key:LORDFXWUHHSAQU-UHFFFAOYSA-N ;
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Trimebutine is a drug with antimuscarinic and very weak mu opioid agonist effects. It is used for the treatment of irritable bowel syndrome and other gastrointestinal disorders. It is sometimes combined with simethicone as a combination drug. Trimebutine is formulated as a tablet or granules for oral suspension.