Mountain West–Missouri Valley Challenge

The Mountain West – Missouri Valley Challenge was an in-season NCAA Division I men's college basketball series, pitting teams from the Mountain West Conference (MW) and the Missouri Valley Conference (MVC). The series began in November 2009 and featured all of the MW teams against most of the MVC teams. The series has not been extended since the conclusion of the 2018 offering.

The first challenge was held in 2009. The conferences agreed to a four-year deal, extending the challenge through 2012. The challenge was not extended beyond its initial term and ended after 2012. However, after a two-year hiatus, it was announced on April 2, 2015 that the conferences would renew the series in 2015 for another four years.

The MW–MVC Challenge occurred from mid-November through mid-December. The games were hosted by each of the institutions. Since its inception, one or more schools sat out each iteration due to unbalanced membership numbers. The first four series had at least one MVC squad without an opponent (including 2011 when two teams were not scheduled). Upon its resumption in 2015, it was the MW that had one team not participating.

The MW leads the eight season series with three wins, one loss, and four ties. Of the schools with more than two decisions, New Mexico (MW, .875) and Wichita State (MVC, .833) have the best percentages for their respective conferences.