Moxidectin

Moxidectin
Clinical data
Trade names	Cydectin, Equest, ProHeart, Quest.
Other names	CL 301,423; milbemycin B.
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth, topical, subcutaneous
ATC code	P02CX03 (WHO) QP54AB02 (WHO), QP54AB52 (WHO);
Legal status
Legal status	CA: ℞-only; US: ℞-only;
Identifiers
	IUPAC name (10E,14E,16E,22Z)-(1R,4S,5′S,6R,6′S,8R,13R,20R,21R,24S)-6′-;
CAS Number	113507-06-5 ;
PubChem CID	9832912;
DrugBank	DB11431;
ChemSpider	16736424 ;
UNII	NGU5H31YO9;
KEGG	D05084 ;
CompTox Dashboard (EPA)	DTXSID5037577 ;
ECHA InfoCard	100.163.046
Chemical and physical data
Formula	C37H53NO8
Molar mass	639.830 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)\C=C(/C)[C@H]5O[C@@]2(C[C@H]1OC(=O)[C@@H]3/C=C(/C)[C@@H](O)[C@H]4OC/C(=C\C=C\[C@H](C)CC(\C)=C\C[C@H](C1)O2)[C@@]34O)C\C(=N\OC)[C@@H]5C;
	InChI InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1 ; Key:YZBLFMPOMVTDJY-CBYMMZEQSA-N ;
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Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle, sheep and wombats. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.