Myelin-associated glycoprotein

MAG
Identifiers
Aliases	MAG, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein
External IDs	OMIM: 159460; MGI: 96912; HomoloGene: 1771; GeneCards: MAG; OMA:MAG - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,313,807 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,614,298 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; inferior ganglion of vagus nerve; ; middle frontal gyrus; ; corpus callosum; ; Pons; ; superior vestibular nucleus; ; subthalamic nucleus; ; external globus pallidus; ; ventral tegmental area; ; pars reticulata;
	Top expressed in
	deep cerebellar nuclei; ; pontine nuclei; ; lateral geniculate nucleus; ; globus pallidus; ; lumbar subsegment of spinal cord; ; dorsal tegmental nucleus; ; ventral tegmental area; ; central gray substance of midbrain; ; Medulla Oblongata; ; medial geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; lipid binding; protein kinase binding; carbohydrate binding; sialic acid binding; protein homodimerization activity; ganglioside GT1b binding;
Cellular component	cytoplasm; plasma membrane; integral component of plasma membrane; membrane; integral component of membrane; paranode region of axon; myelin sheath adaxonal region; myelin sheath; compact myelin; Schmidt-Lanterman incisure; membrane raft; mesaxon;
Biological process	cell adhesion; nervous system development; negative regulation of neuron projection development; substantia nigra development; central nervous system myelination; negative regulation of axon extension; positive regulation of myelination; negative regulation of neuron apoptotic process; negative regulation of neuron differentiation; positive regulation of astrocyte differentiation; negative regulation of axonogenesis; leukocyte migration; cellular response to mechanical stimulus; cell-cell adhesion via plasma-membrane adhesion molecules; transmission of nerve impulse; axon regeneration;
	Sources:Amigo / QuickGO
Orthologs
	4099
	17136
	ENSG00000105695
	ENSMUSG00000036634
	P20916
	P20917
	NM_080600; NM_001199216; NM_002361
NM_010758; NM_001346084; NM_001346085; NM_001346086; NM_001346087;
	NM_001346088; NM_001346089; NM_001369262
	NP_001186145; NP_002352; NP_542167
NP_001333013; NP_001333014; NP_001333015; NP_001333016; NP_001333017;
	NP_001333018; NP_034888; NP_001356191
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin-associated glycoprotein (MAG), or Siglec-4 is a type 1 transmembrane protein, a glycoprotein localized in periaxonal Schwann cell and oligodendrocyte membranes, where it plays a role in glial-axonal interactions. MAG is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. MAG is believed to be involved in myelination during remyelination (nerve regeneration) in the peripheral nervous system (PNS) and is vital for the long-term survival of the myelinated axons following myelinogenesis. In the CNS MAG is one of three main myelin-associated inhibitors of axonal regeneration after injury, making it an important protein for future research on neurogenesis in the CNS.