Myotonin-protein kinase

DMPK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WT6, 2VD5
Identifiers
Aliases	DMPK, DM, DM1, DM1PK, DMK, MDPK, MT-PK, Dm15, dystrophia myotonica protein kinase, DM1 protein kinase
External IDs	OMIM: 605377; MGI: 94906; HomoloGene: 3247; GeneCards: DMPK; OMA:DMPK - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,782,552 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	18,827,746 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right coronary artery; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; right auricle of heart; ; ascending aorta; ; Descending thoracic aorta; ; left uterine tube; ; body of uterus;
	Top expressed in
	myocardium of ventricle; ; muscle of thigh; ; cardiac muscle tissue of left ventricle; ; lip; ; skeletal muscle tissue; ; extraocular muscle; ; interventricular septum; ; soleus muscle; ; ascending aorta; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; myosin phosphatase regulator activity; protein kinase activity; protein binding; kinase activity; metal ion binding; nucleotide binding; transferase activity; heat shock protein binding;
Cellular component	integral component of membrane; mitochondrial outer membrane; nucleus; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; cytosol; membrane; endoplasmic reticulum; mitochondrial membranes; plasma membrane; cytoplasm; nuclear outer membrane; endoplasmic reticulum membrane; mitochondrion; integral component of mitochondrial outer membrane; nuclear membrane;
Biological process	regulation of myotube differentiation; muscle cell apoptotic process; protein phosphorylation; peptidyl-serine phosphorylation; regulation of cardiac conduction; regulation of sodium ion transport; regulation of skeletal muscle contraction by calcium ion signaling; nuclear envelope organization; regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction; regulation of synapse structural plasticity; phosphorylation; cellular calcium ion homeostasis; regulation of heart contraction; regulation of phosphoprotein phosphatase activity; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	1760
	13400
	ENSG00000104936
	ENSMUSG00000030409
	Q09013
	P54265
NM_001081560; NM_001081562; NM_001081563; NM_001288764; NM_001288765;
	NM_001288766; NM_004409
	NM_001190490; NM_001190491; NM_032418; NM_001374651; NM_001379257
NP_001075029; NP_001075031; NP_001075032; NP_001275693; NP_001275694;
	NP_001275695; NP_004400; NP_001275693.1; NP_001275694.1; NP_001275695.1
	NP_001177419; NP_001177420; NP_115794; NP_001361580; NP_001366186
	Wikidata
View/Edit Human	View/Edit Mouse

Myotonin-protein kinase (MT-PK) also known as myotonic dystrophy protein kinase (MDPK) or dystrophia myotonica protein kinase (DMPK) is an enzyme that in humans is encoded by the DMPK gene.

The DMPK gene product is a Ser/Thr protein kinase homologous to the MRCK p21-activated kinases and Rho kinase family. Data obtained by using antibodies that detect specific isoforms of DMPK indicate that the most abundant isoform of DMPK is an 80-kDa protein expressed almost exclusively in smooth, skeletal, and cardiac muscles. This kinase exists both as a membrane-associated and as a soluble form in human left ventricular samples. The different C termini of DMPK that arise from alternative splicing determine its localization to the endoplasmic reticulum, mitochondria, or cytosol in transfected COS-1 cells. Among the substrates for DMPK proposed by in vitro studies are phospholemman, the dihydropyridine receptor, and the myosin phosphatase targeting subunit. However, an in vivo demonstration of the phosphorylation of these substrates by DMPK remains to be established, and a link between these substrates and the clinical manifestations of myotonic dystrophy (DM) is unclear.