N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.2.33 | ||||||||
| CAS no. | 242469-38-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gene)) is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase. This enzyme catalyses the following chemical reaction
- (1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
- (2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
The enzyme is activated by divalent cations and reduced glutathione.