Glycylpeptide N-tetradecanoyltransferase 1

NMT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RXT, 3IU1, 3IU2, 3IWE, 3JTK, 4C2Y, 4C2Z
Identifiers
Aliases	NMT1, Nmt1, AW536594, NMT, N-myristoyltransferase 1
External IDs	OMIM: 160993; MGI: 102579; HomoloGene: 69027; GeneCards: NMT1; OMA:NMT1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	45,109,016 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,959,738 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right adrenal gland; ; islet of Langerhans; ; sural nerve; ; gastrocnemius muscle; ; left adrenal gland; ; right adrenal cortex; ; Achilles tendon; ; left adrenal cortex; ; granulocyte;
	Top expressed in
	Ileal epithelium; ; endothelial cell of lymphatic vessel; ; vestibular membrane of cochlear duct; ; Paneth cell; ; primitive streak; ; lacrimal gland; ; gastrula; ; decidua; ; interventricular septum; ; hair follicle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; acyltransferase activity; glycylpeptide N-tetradecanoyltransferase activity; myristoyltransferase activity;
Cellular component	membrane; plasma membrane; extrinsic component of membrane; cytoplasm; mitochondrion; cytosol;
Biological process	regulation of rhodopsin mediated signaling pathway; in utero embryonic development; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; N-terminal peptidyl-glycine N-myristoylation; N-terminal protein myristoylation; cellular ketone metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4836
	18107
	ENSG00000136448
	ENSMUSG00000020936
	P30419
	O70310
	NM_021079
	NM_008707
	NP_066565
	NP_032733
	Wikidata
View/Edit Human	View/Edit Mouse

Glycylpeptide N-tetradecanoyltransferase 1 also known as myristoyl-CoA:protein N-myristoyltransferase 1 (NMT-1) is an enzyme that in humans is encoded by the NMT1 gene. It belongs to the protein N-terminal methyltransferase and glycylpeptide N-tetradecanoyltransferase family of enzymes. This enzyme can be inhibited by NMT inhibitors.