N-terminal telopeptide

N-terminal telopeptide
Names
Other names
NTX; N-terminal crosslinked telopeptides of collagen 1; Collagen alpha-1(IX) chain
Identifiers
3D model (JSmol)
  • InChI=1S/C35H53N9O16/c1-17(46)29(35(60)39-14-25(48)38-15-28(53)54)44-34(59)24(16-45)43-31(56)21(4-2-3-11-36)40-32(57)22(9-10-26(49)50)41-33(58)23(13-27(51)52)42-30(55)20(37)12-18-5-7-19(47)8-6-18/h5-8,17,20-24,29,45-47H,2-4,9-16,36-37H2,1H3,(H,38,48)(H,39,60)(H,40,57)(H,41,58)(H,42,55)(H,43,56)(H,44,59)(H,49,50)(H,51,52)(H,53,54)/t17-,20+,21+,22+,23+,24+,29+/m1/s1
    Key: NDMSLYATKUJCPL-DMTHXQJOSA-N
  • [C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)N)=O)CC(O)=O)=O)CCC(O)=O)=O)(C(N[C@H](C(N[C@H](C(NCC(NCC(O)=O)=O)=O)[C@@H](C)O)=O)CO)=O)CCCCN
Properties
C35H53N9O16
Molar mass 855.856 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

The N-terminal telopeptide (NTX), also known as amino-terminal collagen crosslinks, is the N-terminal telopeptide of fibrillar collagens such as collagen type I and type II. It is used as a biomarker to measure the rate of bone turnover. NTX can be measured in the urine (uNTX) or serum (serum NTX). The peptide consists of eight amino acids with the sequence YDEKSTGG.