NADSYN1

NADSYN1
Identifiers
Aliases	NADSYN1, NAD synthetase 1, VCRL3
External IDs	OMIM: 608285; MGI: 1926164; HomoloGene: 6098; GeneCards: NADSYN1; OMA:NADSYN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	71,524,107 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	143,376,586 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; granulocyte; ; mucosa of transverse colon; ; anterior pituitary; ; minor salivary glands; ; left ovary; ; right lung; ; skin of leg; ; rectum; ; body of stomach;
	Top expressed in
	duodenum; ; jejunum; ; proximal tubule; ; yolk sac; ; right kidney; ; left lobe of liver; ; epithelium of small intestine; ; colon; ; ileum; ; human kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ligase activity; protein binding; ATP binding; glutaminase activity; NAD+ synthase (glutamine-hydrolyzing) activity;
Cellular component	cytoplasm; cytosol;
Biological process	nitrogen compound metabolic process; NAD metabolic process; NAD biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	55191
	78914
	ENSG00000172890
	ENSMUSG00000031090
	Q6IA69
	Q711T7
	NM_018161
	NM_030221; NM_001308092; NM_001308095
	NP_060631
	NP_001295024; NP_084497
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamine-dependent NAD(+) synthetase is an enzyme that in humans is encoded by the NADSYN1 gene.

Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).