NAGA (gene)

NAGA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DO5, 3H53, 3IGU, 4DO4, 4DO6, 3H54, 3H55
Identifiers
Aliases	NAGA, D22S674, GALB, alpha-N-acetylgalactosaminidase
External IDs	OMIM: 104170; MGI: 1261422; HomoloGene: 221; GeneCards: NAGA; OMA:NAGA - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	42,070,842 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,223,126 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; stromal cell of endometrium; ; gonad; ; gallbladder; ; rectum; ; placenta; ; appendix; ; Descending thoracic aorta; ; olfactory zone of nasal mucosa;
	Top expressed in
	islet of Langerhans; ; choroid plexus of fourth ventricle; ; yolk sac; ; right kidney; ; decidua; ; stomach; ; stroma of bone marrow; ; epithelium of stomach; ; lacrimal gland; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity, hydrolyzing O-glycosyl compounds; alpha-N-acetylgalactosaminidase activity; hydrolase activity; protein homodimerization activity; alpha-galactosidase activity; catalytic activity; hydrolase activity, acting on glycosyl bonds;
Cellular component	cytoplasm; lysosome; extracellular exosome;
Biological process	carbohydrate catabolic process; metabolism; glycoside catabolic process; glycolipid catabolic process; oligosaccharide metabolic process; glycosylceramide catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4668
	17939
	ENSG00000198951
	ENSMUSG00000022453
	P17050
	Q9QWR8
	NM_000262; NM_001362848; NM_001362850
	NM_008669; NM_001355546
	NP_000253; NP_001349777; NP_001349779; NP_000253.1
	NP_032695; NP_001342475
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-N-acetylgalactosaminidase is an enzyme that in humans is encoded by the NAGA gene.

NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease).