NANS

NANS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WVO
Identifiers
Aliases	NANS, HEL-S-100, SAS, N-acetylneuraminate synthase, SEMDG, SEMDCG
External IDs	OMIM: 605202; MGI: 2149820; HomoloGene: 10343; GeneCards: NANS; OMA:NANS - orthologs
EC number	2.5.1.57
Gene location (Human)
Chr.	Chromosome 9 (human)
End	98,083,077 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	46,503,632 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; mucosa of transverse colon; ; rectum; ; epithelium of nasopharynx; ; olfactory zone of nasal mucosa; ; palpebral conjunctiva; ; parotid gland; ; prostate; ; trachea; ; bronchial epithelial cell;
	Top expressed in
	left colon; ; submandibular gland; ; lacrimal gland; ; seminal vesicula; ; basilar part of occipital bone; ; parotid gland; ; crypt of lieberkuhn of small intestine; ; prostate; ; endothelial cell of lymphatic vessel; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	N-acetylneuraminate synthase activity; transferase activity; catalytic activity; N-acylneuraminate cytidylyltransferase activity; N-acylneuraminate-9-phosphate synthase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	carbohydrate biosynthetic process; CMP-N-acetylneuraminate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	54187
	94181
	ENSG00000095380
	ENSMUSG00000028334
	Q9NR45; Q5TBR0
	Q99J77
	NM_018946
	NM_053179
	NP_061819
	NP_444409
	Wikidata
View/Edit Human	View/Edit Mouse

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.