NAP1L4

NAP1L4
Identifiers
Aliases	NAP1L4, NAP1L4b, NAP2, NAP2L, hNAP2, nucleosome assembly protein 1 like 4
External IDs	OMIM: 601651; MGI: 1316687; HomoloGene: 133933; GeneCards: NAP1L4; OMA:NAP1L4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,992,377 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	143,549,106 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; C1 segment; ; Achilles tendon; ; left testis; ; right testis; ; bone marrow cells; ; sural nerve; ; apex of heart; ; epithelium of colon;
	Top expressed in
	saccule; ; ectoderm; ; otic placode; ; otic vesicle; ; lens; ; epithelium of lens; ; medullary collecting duct; ; superior cervical ganglion; ; ventricular zone; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein binding; RNA binding; nucleosome binding;
Cellular component	nucleus; cytoplasm;
Biological process	nucleosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	4676
	17955
	ENSG00000205531; ENSG00000273562
	ENSMUSG00000059119
	Q99733
	Q78ZA7
	NM_005969
	NM_001285489; NM_001285490; NM_008672
NP_005960; NP_001356304; NP_001356305; NP_001356306; NP_001356307;
	NP_001356308; NP_001356309; NP_001356310; NP_001356311; NP_001356312; NP_001356313; NP_001356314; NP_001356315; NP_001356317; NP_005960.1
	NP_001272418; NP_001272419; NP_032698
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.