NAPSA

NAPSA
Identifiers
Aliases	NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin A aspartic peptidase
External IDs	OMIM: 605631; MGI: 109365; HomoloGene: 68418; GeneCards: NAPSA; OMA:NAPSA - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,365,830 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,236,286 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; upper lobe of lung; ; upper lobe of left lung; ; visceral pleura; ; right lung; ; human kidney; ; testicle; ; right uterine tube; ; mucosa of transverse colon; ; caput epididymis;
	Top expressed in
	right kidney; ; human kidney; ; left lung; ; right lung; ; left lung lobe; ; right lung lobe; ; proximal tubule; ; spleen; ; granulocyte; ; tibiofemoral joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	endopeptidase activity; hydrolase activity; aspartic-type endopeptidase activity; peptidase activity;
Cellular component	extracellular region; lysosome; extracellular exosome; alveolar lamellar body; multivesicular body lumen; extracellular space;
Biological process	surfactant homeostasis; protein catabolic process; proteolysis; membrane protein proteolysis; autophagy;
	Sources:Amigo / QuickGO
Orthologs
	9476
	16541
	ENSG00000131400
	ENSMUSG00000002204
	O96009
	O09043
	NM_004851
	NM_008437
	NP_004842
	NP_032463
	Wikidata
View/Edit Human	View/Edit Mouse

Napsin-A is an aspartic proteinase that is encoded in humans by the NAPSA gene. The name napsin comes from novel aspartic proteinase of the pepsin family.

The activation peptide of an aspartic proteinase acts as an inhibitor of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.