N-acetyltransferase 1

NAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IJA, 2PQT
Identifiers
Aliases	NAT1, AAC1, MNAT, NAT-1, NATI, N-acetyltransferase 1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
External IDs	OMIM: 108345; MGI: 109201; HomoloGene: 37329; GeneCards: NAT1; OMA:NAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	18,223,689 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	67,955,236 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; epithelium of nasopharynx; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; jejunal mucosa; ; mucosa of paranasal sinus; ; mucosa of transverse colon;
	Top expressed in
	jejunum; ; fetal liver hematopoietic progenitor cell; ; duodenum; ; epithelium of stomach; ; left lobe of liver; ; ileum; ; epithelium of small intestine; ; lumbar spinal ganglion; ; left colon; ; mucous cell of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	arylamine N-acetyltransferase activity; transferase activity; acetyltransferase activity; acyltransferase activity; N-acetyltransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	xenobiotic metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	9
	17961
	ENSG00000171428
	ENSMUSG00000051147
	P18440; Q400J6
	P50295
NM_000662; NM_001160170; NM_001160171; NM_001160172; NM_001160173;
	NM_001160174; NM_001160175; NM_001160176; NM_001160179; NM_001291962
	NM_001168577; NM_010874
NP_000653; NP_001153642; NP_001153643; NP_001153644; NP_001153645;
	NP_001153646; NP_001153647; NP_001153648; NP_001153651; NP_001278891; NP_001153642.1; NP_001153644.1; NP_001153645.1; NP_001153646.1; NP_001153647.1
	NP_001162049; NP_035004
	Wikidata
View/Edit Human	View/Edit Mouse

N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene.

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat NAT2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].