Nibrin

NBN
Identifiers
Aliases	NBN, AT-V1, AT-V2, ATV, NBS, NBS1, P95, nibrin
External IDs	OMIM: 602667; MGI: 1351625; HomoloGene: 1858; GeneCards: NBN; OMA:NBN - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	90,003,228 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	15,992,589 bp
RNA expression pattern
	Top expressed in
	lactiferous duct; ; tail of epididymis; ; trigeminal ganglion; ; germinal epithelium; ; parietal pleura; ; decidua; ; superior surface of tongue; ; Achilles tendon; ; palpebral conjunctiva; ; bone marrow;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; intercostal muscle; ; genital tubercle; ; tail of embryo; ; epiblast; ; primitive streak; ; medial head of gastrocnemius muscle; ; somite;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; DNA helicase activity; transcription factor binding; protein binding; damaged DNA binding;
Cellular component	site of double-strand break; cytosol; PML body; replication fork; nucleoplasm; chromosome; telomere; nucleolus; nuclear inclusion body; nucleus; Mre11 complex;
Biological process	regulation of DNA-dependent DNA replication initiation; neuromuscular process controlling balance; mitotic cell cycle checkpoint signaling; positive regulation of kinase activity; telomeric 3' overhang formation; DNA damage checkpoint signaling; DNA damage response, signal transduction by p53 class mediator; in utero embryonic development; cellular response to DNA damage stimulus; intrinsic apoptotic signaling pathway; positive regulation of telomere maintenance; negative regulation of telomere capping; DNA duplex unwinding; meiosis; positive regulation of protein autophosphorylation; isotype switching; cell cycle; blastocyst growth; cell population proliferation; mitotic G2 DNA damage checkpoint signaling; double-strand break repair via nonhomologous end joining; telomere maintenance; double-strand break repair via homologous recombination; DNA synthesis involved in DNA repair; DNA repair; regulation of signal transduction by p53 class mediator; strand displacement; DNA replication; double-strand break repair; DNA double-strand break processing; t-circle formation; telomere maintenance via telomere trimming; telomere capping; signal transduction in response to DNA damage;
	Sources:Amigo / QuickGO
Orthologs
	4683
	27354
	ENSG00000104320
	ENSMUSG00000028224
	O60934
	Q9R207
	NM_001024688; NM_002485
	NM_013752
	NP_001019859; NP_002476
	NP_038780
	Wikidata
View/Edit Human	View/Edit Mouse

Nibrin, also known as NBN or NBS1, is a protein which in humans is encoded by the NBN gene.