Neutral cholesterol ester hydrolase 1

NCEH1
Identifiers
Aliases	NCEH1, AADACL1, NCEH, neutral cholesterol ester hydrolase 1
External IDs	OMIM: 613234; MGI: 2443191; HomoloGene: 23251; GeneCards: NCEH1; OMA:NCEH1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	172,711,218 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	27,338,757 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; secondary oocyte; ; islet of Langerhans; ; prefrontal cortex; ; Brodmann area 9; ; superior frontal gyrus; ; right ventricle; ; postcentral gyrus; ; primary visual cortex; ; caudate nucleus;
	Top expressed in
	interventricular septum; ; secondary oocyte; ; primary oocyte; ; otolith organ; ; myocardium of ventricle; ; utricle; ; epithelium of stomach; ; human kidney; ; right kidney; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	carboxylic ester hydrolase activity; hydrolase activity; sterol esterase activity; serine hydrolase activity;
Cellular component	integral component of membrane; endoplasmic reticulum; intracellular membrane-bounded organelle; endoplasmic reticulum membrane; membrane;
Biological process	lipid catabolic process; metabolism; lipid metabolism; catabolic process; xenobiotic metabolic process; low-density lipoprotein particle clearance;
	Sources:Amigo / QuickGO
Orthologs
	57552
	320024
	ENSG00000144959
	ENSMUSG00000027698
	Q6PIU2
	Q8BLF1
	NM_020792; NM_001146276; NM_001146277; NM_001146278
	NM_178772
	NP_001139748; NP_001139749; NP_001139750; NP_065843
	NP_848887
	Wikidata
View/Edit Human	View/Edit Mouse

Neutral cholesterol ester hydrolase 1 (NCEH) also known as arylacetamide deacetylase-like 1 (AADACL1) or KIAA1363 is an enzyme that in humans is encoded by the NCEH1 gene.

NCEH is an enzyme located in the endoplasmic reticulum. NCEH hydrolyzes 2-acetyl monoalkylglycerol ether, as part of an enzymatic pathway regulating the levels of platelet activating factor and lysophospholipids that may be involved in cancer development.