Neutrophil cytosolic factor 1

NCF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GD5, 1K4U, 1KQ6, 1NG2, 1O7K, 1OV3, 1UEC, 1W70, 1WLP
Identifiers
Aliases	NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox, Neutrophil cytosolic factor 1, CGD1
External IDs	OMIM: 608512; MGI: 97283; HomoloGene: 30964; GeneCards: NCF1; OMA:NCF1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	74,789,315 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	134,258,479 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; bone marrow cells; ; spleen; ; appendix; ; lymph node; ; upper lobe of left lung; ; right lung; ; mucosa of transverse colon;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; mesenteric lymph nodes; ; tibiofemoral joint; ; blood; ; spleen; ; calvaria; ; transitional epithelium of urinary bladder; ; left lung lobe; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	superoxide-generating NAD(P)H oxidase activity; SH3 domain binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; phosphatidylinositol binding; electron transfer activity; lipid binding; superoxide-generating NADPH oxidase activator activity;
Cellular component	cytoplasm; cytosol; membrane; phagolysosome; extrinsic component of membrane; dendrite; NADPH oxidase complex; Golgi apparatus; rough endoplasmic reticulum; soma; podosome; plasma membrane;
Biological process	protein targeting to membrane; superoxide anion generation; cellular defense response; vascular endothelial growth factor receptor signaling pathway; innate immune response; superoxide metabolic process; apoptotic process; respiratory burst; podosome assembly; positive regulation of phosphatidylinositol 3-kinase signaling; cellular response to reactive oxygen species; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of transcription, DNA-templated; positive regulation of JNK cascade; cellular response to cadmium ion; positive regulation of p38MAPK cascade; electron transport chain; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cellular response to oxidative stress; cell redox homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	653361
	17969
	ENSG00000158517
	ENSMUSG00000015950
	P14598
	Q09014
	NM_000265
	NM_001286037; NM_010876
	NP_000256
	NP_001272966; NP_035006
	Wikidata
View/Edit Human	View/Edit Mouse

Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene.