Neutrophil cytosolic factor 4

NCF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H6H, 1OEY, 1W6X, 1W70, 1Z9Q, 2DYB
Identifiers
Aliases	NCF4, NCF, P40PHOX, SH3PXD4, Neutrophil cytosolic factor 4, CGD3
External IDs	OMIM: 601488; MGI: 109186; HomoloGene: 525; GeneCards: NCF4; OMA:NCF4 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,878,017 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,146,780 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; granulocyte; ; bone marrow; ; monocyte; ; bone marrow cells; ; appendix; ; lymph node; ; synovial membrane; ; placenta;
	Top expressed in
	granulocyte; ; blood; ; tibiofemoral joint; ; spleen; ; mesenteric lymph nodes; ; bone marrow; ; fetal liver hematopoietic progenitor cell; ; stroma of bone marrow; ; embryo; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; phosphatidylinositol-3-phosphate binding; protein binding; phosphatidylinositol binding; lipid binding; superoxide-generating NADPH oxidase activator activity;
Cellular component	cytoplasm; cytosol; endosome; membrane; phagolysosome; endosome membrane; trans-Golgi network; NADPH oxidase complex;
Biological process	vascular endothelial growth factor receptor signaling pathway; immune response; positive regulation of catalytic activity; vesicle-mediated transport; phagocytosis; respiratory burst; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cellular response to oxidative stress; cell redox homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	4689
	17972
	ENSG00000275990; ENSG00000100365
	ENSMUSG00000071715
	Q15080
	P97369
	NM_000631; NM_013416
	NM_008677
	NP_000622; NP_038202
	NP_032703
	Wikidata
View/Edit Human	View/Edit Mouse

Neutrophil cytosol factor 4 is a protein that in humans is encoded by the NCF4 gene.