NCK1

NCK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CI8, 2CI9, 2JS0, 2JS2, 2JW4
Identifiers
Aliases	NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1
External IDs	OMIM: 600508; MGI: 109601; HomoloGene: 38148; GeneCards: NCK1; OMA:NCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	136,951,606 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	100,428,187 bp
RNA expression pattern
	Top expressed in
	human penis; ; Achilles tendon; ; oral cavity; ; epithelium of nasopharynx; ; decidua; ; palpebral conjunctiva; ; tonsil; ; vagina; ; gums; ; skin of thigh;
	Top expressed in
	granulocyte; ; atrioventricular valve; ; tail of embryo; ; esophagus; ; spermatocyte; ; masseter muscle; ; intercostal muscle; ; uterus; ; saccule; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein domain specific binding; receptor tyrosine kinase binding; protein kinase inhibitor activity; protein binding; cytoskeletal anchor activity; signaling receptor complex adaptor activity; signaling receptor binding; eukaryotic initiation factor eIF2 binding; ephrin receptor binding; cadherin binding; molecular adaptor activity;
Cellular component	cytosol; ribosome; cell-cell junction; vesicle membrane; protein phosphatase type 1 complex; endoplasmic reticulum; nucleus; cytoplasm; plasma membrane;
Biological process	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; actin filament organization; positive regulation of translation in response to endoplasmic reticulum stress; substrate-dependent cell migration, cell extension; signal complex assembly; negative regulation of cell death; positive regulation of cap-independent translational initiation; positive regulation of cap-dependent translational initiation; peptidyl-serine dephosphorylation; vascular endothelial growth factor receptor signaling pathway; response to other organism; positive regulation of T cell proliferation; negative regulation of peptidyl-serine phosphorylation; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; T cell receptor signaling pathway; negative regulation of PERK-mediated unfolded protein response; cell migration; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of translation; T cell activation; lamellipodium assembly; positive regulation of transcription by RNA polymerase II; negative regulation of protein kinase activity; positive regulation of actin filament polymerization; regulation of cell migration; ephrin receptor signaling pathway; positive regulation of neuron projection development; negative regulation of insulin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4690
	17973
	ENSG00000158092
	ENSMUSG00000032475
	P16333
	Q99M51
	NM_006153; NM_001190796; NM_001291999
	NM_010878; NM_001324530
	NP_001177725; NP_001278928; NP_006144
	NP_001311459; NP_035008
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.