NCK2

NCK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U5S, 1WX6, 1Z3K, 2B86, 2CIA, 2FRW, 2FRY, 2JXB, 4E6R
Identifiers
Aliases	NCK2, GRB4, NCKbeta, NCK adaptor protein 2
External IDs	OMIM: 604930; MGI: 1306821; HomoloGene: 20794; GeneCards: NCK2; OMA:NCK2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	105,894,274 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	43,609,675 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; parotid gland; ; secondary oocyte; ; Region I of hippocampus proper; ; ganglionic eminence; ; cartilage tissue; ; duodenum; ; olfactory zone of nasal mucosa; ; gums; ; gastric mucosa;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; thymus; ; lip; ; tail of embryo; ; yolk sac; ; primary visual cortex; ; spermatid; ; right kidney; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	scaffold protein binding; protein binding; cytoskeletal anchor activity; signaling receptor complex adaptor activity; phosphotyrosine residue binding; protein-containing complex binding;
Cellular component	cytosol; vesicle membrane; synapse; endoplasmic reticulum; cytoplasm; postsynaptic density;
Biological process	positive regulation of actin filament polymerization; epidermal growth factor receptor signaling pathway; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; actin filament organization; positive regulation of translation in response to endoplasmic reticulum stress; ephrin receptor signaling pathway; signal complex assembly; dendritic spine development; vascular endothelial growth factor receptor signaling pathway; positive regulation of T cell proliferation; negative regulation of peptidyl-serine phosphorylation; regulation of epidermal growth factor-activated receptor activity; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; immunological synapse formation; cell migration; negative regulation of PERK-mediated unfolded protein response; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; T cell activation; regulation of translation; lamellipodium assembly; signal transduction; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8440
	17974
	ENSG00000071051
	ENSMUSG00000066877
	O43639
	O55033
	NM_001004720; NM_001004722; NM_003581
	NM_010879
	NP_001004720; NP_001004722; NP_003572
	NP_035009
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene.