NCOA4

NCOA4
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1T5Z
Identifiers
Aliases	NCOA4, ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
External IDs	OMIM: 601984; MGI: 1350932; HomoloGene: 38052; GeneCards: NCOA4; OMA:NCOA4 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	46,030,623 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	31,901,812 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; trabecular bone; ; visceral pleura; ; parietal pleura; ; epithelium of nasopharynx; ; palpebral conjunctiva; ; gingival epithelium; ; tibia; ; kidney tubule; ; Epithelium of choroid plexus;
	Top expressed in
	spermatid; ; spermatocyte; ; zygote; ; secondary oocyte; ; granulocyte; ; duodenum; ; primary oocyte; ; bone marrow; ; liver; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	androgen receptor binding; transcription coactivator activity;
Cellular component	nucleus; autolysosome;
Biological process	androgen receptor signaling pathway; positive regulation of transcription, DNA-templated; male gonad development; transcription, DNA-templated; regulation of transcription, DNA-templated; protein targeting to lysosome; cellular iron ion homeostasis; response to hormone;
	Sources:Amigo / QuickGO
Orthologs
	8031
	27057
	ENSG00000266412
	ENSMUSG00000056234
	Q13772
	n/a
	NM_005437; NM_001145260; NM_001145261; NM_001145262; NM_001145263
	NM_001033988; NM_001284319; NM_019744
	NP_001138732; NP_001138733; NP_001138734; NP_001138735; NP_005428
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.