Nicastrin

NCSTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UPC, 5A63, 4UIS, 5FN3, 5FN4, 5FN5, 5FN2, 2N7R, 2N7Q
Identifiers
Aliases	NCSTN, ATAG1874, nicastrin
External IDs	OMIM: 605254; MGI: 1891700; HomoloGene: 41029; GeneCards: NCSTN; OMA:NCSTN - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,358,952 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,910,362 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; monocyte; ; body of pancreas; ; granulocyte; ; rectum; ; islet of Langerhans; ; olfactory bulb; ; right lung; ; minor salivary glands; ; ventricular zone;
	Top expressed in
	spermatocyte; ; lip; ; genital tubercle; ; granulocyte; ; tail of embryo; ; right kidney; ; ventricular zone; ; epithelium of small intestine; ; stroma of bone marrow; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; protein binding; endopeptidase activity;
Cellular component	Golgi apparatus; membrane; focal adhesion; melanosome; plasma membrane; integral component of plasma membrane; lysosomal membrane; endoplasmic reticulum; extracellular exosome; integral component of membrane; azurophil granule membrane; gamma-secretase complex; cytoplasmic vesicle membrane; cytoplasmic vesicle; cytoplasm; mitochondrion; lysosome; early endosome; synaptic vesicle; endosome membrane; protein-containing complex; sarcolemma; synapse; synaptic membrane; integral component of presynaptic membrane;
Biological process	Notch signaling pathway; ephrin receptor signaling pathway; myeloid cell homeostasis; protein processing; positive regulation of catalytic activity; amyloid-beta metabolic process; epithelial cell proliferation; proteolysis; T cell proliferation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; positive regulation of apoptotic process; Notch receptor processing; amyloid precursor protein catabolic process; amyloid-beta formation; amyloid precursor protein metabolic process; neutrophil degranulation; cerebellum development; Notch receptor processing, ligand-dependent; dopamine receptor signaling pathway; glutamate receptor signaling pathway; learning or memory; central nervous system myelination; adult behavior; amyloid precursor protein biosynthetic process; positive regulation of amyloid precursor protein biosynthetic process; neuron apoptotic process; neuron death; cellular response to calcium ion; regulation of long-term synaptic potentiation; short-term synaptic potentiation;
	Sources:Amigo / QuickGO
Orthologs
	23385
	59287
	ENSG00000162736
	ENSMUSG00000003458
	Q92542
	P57716
	NM_001290184; NM_001290186; NM_015331; NM_001349729
	NM_021607
	NP_001277113; NP_001277115; NP_056146; NP_001336658
	NP_067620
	Wikidata
View/Edit Human	View/Edit Mouse

Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene.