NDRG1

NDRG1
Identifiers
Aliases	NDRG1, CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5, N-myc downstream regulated 1
External IDs	OMIM: 605262; MGI: 1341799; HomoloGene: 55953; GeneCards: NDRG1; OMA:NDRG1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	133,302,022 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	66,841,489 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; internal globus pallidus; ; tibial nerve; ; corpus callosum; ; inferior olivary nucleus; ; skin of abdomen; ; inferior ganglion of vagus nerve; ; trigeminal ganglion; ; skin of leg; ; C1 segment;
	Top expressed in
	sciatic nerve; ; epithelium of lens; ; human kidney; ; migratory enteric neural crest cell; ; right kidney; ; proximal tubule; ; suprachiasmatic nucleus; ; utricle; ; ciliary body; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; cadherin binding; protein binding; gamma-tubulin binding;
Cellular component	cytoplasm; centrosome; membrane; microtubule cytoskeleton; myelin sheath; plasma membrane; microtubule organizing center; recycling endosome membrane; perinuclear region of cytoplasm; microtubule; extracellular exosome; cytoskeleton; nucleus; cytosol; glutamatergic synapse;
Biological process	mast cell activation; peripheral nervous system myelin maintenance; DNA damage response, signal transduction by p53 class mediator; response to metal ion; positive regulation of spindle checkpoint; regulation of cell population proliferation; cellular response to hypoxia; negative regulation of cell population proliferation; regulation of apoptotic process; signal transduction; postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
	10397
	17988
	ENSG00000104419
	ENSMUSG00000005125
	Q92597
	Q62433
NM_001135242; NM_001258432; NM_001258433; NM_006096; NM_001374844;
	NM_001374845; NM_001374846; NM_001374847
	NM_008681
NP_001128714; NP_001245361; NP_001245362; NP_006087; NP_001361773;
	NP_001361774; NP_001361775; NP_001361776
	NP_032707
	Wikidata
View/Edit Human	View/Edit Mouse

Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation . Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D.

It has been reported that NDRG1 localizes to the endosomes and is a Rab4a effector involved in vesicular recycling.

As reviewed by Fang et al., NDRG1 is involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses, immunity, DNA repair and cell adhesion among other functions. NDRG1 is localised in the cytoplasm, nucleus and mitochondrion, at probabilities of 47.8%, 26.1% and 8.7%, respectively. In response to DNA damage NDRG1 translocates from the cytoplasm to the nucleus, where it may inhibit cell growth and promote DNA repair mechanisms. It is suggested that NDRG1 acts as a stress response gene or potentially as a transcription factor.