NDUFA10

NDUFA10
Identifiers
Aliases	NDUFA10, CI-42KD, CI-42k, NADH:ubiquinone oxidoreductase subunit A10, MC1DN22
External IDs	OMIM: 603835; MGI: 1914523; HomoloGene: 15342; GeneCards: NDUFA10; OMA:NDUFA10 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	240,025,743 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	92,401,582 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; right auricle of heart; ; mucosa of transverse colon; ; right ventricle; ; right adrenal gland; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; rectum;
	Top expressed in
	right ventricle; ; digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; temporal muscle; ; right kidney; ; muscle of thigh; ; vastus lateralis muscle; ; facial motor nucleus; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity;
Cellular component	mitochondrial inner membrane; myelin sheath; mitochondrial matrix; respirasome; mitochondrion; mitochondrial respiratory chain complex I; cytoplasm;
Biological process	mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly;
	Sources:Amigo / QuickGO
Orthologs
	4705
	67273
	ENSG00000130414
	ENSMUSG00000026260
	O95299
	Q99LC3
	NM_004544; NM_001322019; NM_001322020
	NM_024197
	NP_001308948; NP_001308949; NP_004535
	NP_077159
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10 is an enzyme that in humans is encoded by the NDUFA10 gene. The NDUFA10 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Mutations in subunits of NADH dehydrogenase (ubiquinone), also known as Complex I, frequently lead to complex neurodegenerative diseases such as Leigh's syndrome. Furthermore, reduced NDUFA10 expression levels due to FOXM1-directed hypermethylation are associated with human squamous cell carcinoma and may be related to other forms of cancer.