NDUFA6

NDUFA6
Identifiers
Aliases	NDUFA6, B14, CI-B14, LYRM6, NADHB14, NADH:ubiquinone oxidoreductase subunit A6, MC1DN33
External IDs	OMIM: 602138; MGI: 1914380; HomoloGene: 1861; GeneCards: NDUFA6; OMA:NDUFA6 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	42,090,884 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,238,523 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; left ventricle; ; right auricle of heart; ; apex of heart; ; gastrocnemius muscle; ; skeletal muscle tissue; ; human kidney; ; mucosa of transverse colon; ; ganglionic eminence; ; renal cortex;
	Top expressed in
	right kidney; ; facial motor nucleus; ; muscle of thigh; ; digastric muscle; ; proximal tubule; ; temporal muscle; ; intercostal muscle; ; sternocleidomastoid muscle; ; atrioventricular valve; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity;
Cellular component	mitochondrial inner membrane; mitochondrial respiratory chain complex I; respirasome; mitochondrial membranes; mitochondrion; membrane;
Biological process	response to oxidative stress; mitochondrial respiratory chain complex I assembly; mitochondrial electron transport, NADH to ubiquinone;
	Sources:Amigo / QuickGO
Orthologs
	4700
	67130
ENSG00000273397; ENSG00000184983; ENSG00000272765; ENSG00000281013; ENSG00000277365;
	n/a
	ENSMUSG00000022450
	P56556
	Q9CQZ5
	NM_002490
	NM_025987
	NP_002481
	NP_080263
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 is an enzyme that in humans is encoded by the NDUFA6 gene. It belongs to the superfamily of LYRM proteins, which are characterized by a conserved leucine–tyrosine–arginine motif. The NDUFA6 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.