NDUFB3

NDUFB3
Identifiers
Aliases	NDUFB3, B12, CI-B12, NADH:ubiquinone oxidoreductase subunit B3, MC1DN25
External IDs	OMIM: 603839; MGI: 1913745; HomoloGene: 37630; GeneCards: NDUFB3; OMA:NDUFB3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,085,750 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,635,123 bp
RNA expression pattern
	Top expressed in
	right auricle of heart; ; left ventricle; ; apex of heart; ; muscle of thigh; ; mucosa of transverse colon; ; biceps brachii; ; right ventricle; ; gastrocnemius muscle; ; thoracic diaphragm; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	facial motor nucleus; ; soleus muscle; ; interventricular septum; ; plantaris muscle; ; intercostal muscle; ; brown adipose tissue; ; masseter muscle; ; digastric muscle; ; ankle joint; ; extensor digitorum longus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex I; respirasome; membrane; mitochondrion;
Biological process	electron transport chain; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly;
	Sources:Amigo / QuickGO
Orthologs
	4709
	66495
	ENSG00000119013
	ENSMUSG00000026032
	O43676
	Q9CQZ6
	NM_001257102; NM_002491
	NM_025597
	NP_001244031; NP_002482
	NP_079873
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa is a protein that in humans is encoded by the NDUFB3 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain. Mutations in this gene contribute to mitochondrial complex I deficiency.