NDUFS1

NDUFS1
Identifiers
Aliases	NDUFS1, CI-75Kd, CI-75k, PRO1304, NADH:ubiquinone oxidoreductase core subunit S1, MC1DN5
External IDs	OMIM: 157655; MGI: 2443241; HomoloGene: 3670; GeneCards: NDUFS1; OMA:NDUFS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	206,159,509 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	63,215,992 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; skeletal muscle tissue; ; muscle of leg; ; gastrocnemius muscle; ; muscle of thigh; ; left ventricle; ; apex of heart; ; right auricle of heart; ; islet of Langerhans; ; rectum;
	Top expressed in
	myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; digastric muscle; ; extraocular muscle; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; soleus muscle; ; temporal muscle; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; NADH dehydrogenase activity; electron transfer activity; oxidoreductase activity; 2 iron, 2 sulfur cluster binding; oxidoreductase activity, acting on NAD(P)H; 4 iron, 4 sulfur cluster binding; protein binding; NADH dehydrogenase (ubiquinone) activity; iron-sulfur cluster binding;
Cellular component	respirasome; mitochondrion; mitochondrial matrix; mitochondrial respiratory chain complex I; membrane; mitochondrial intermembrane space; myelin sheath; mitochondrial inner membrane; plasma membrane respiratory chain complex I;
Biological process	ATP synthesis coupled electron transport; ATP metabolic process; reactive oxygen species metabolic process; mitochondrial respiratory chain complex I assembly; regulation of mitochondrial membrane potential; apoptotic mitochondrial changes; cellular respiration; mitochondrial electron transport, NADH to ubiquinone;
	Sources:Amigo / QuickGO
Orthologs
	4719
	227197
	ENSG00000023228; ENSG00000283447
	ENSMUSG00000025968
	P28331
	Q91VD9
	NM_005006; NM_001199981; NM_001199982; NM_001199983; NM_001199984
	NM_001160038; NM_001160039; NM_001160040; NM_145518
	NP_001186910; NP_001186911; NP_001186912; NP_001186913; NP_004997
	NP_001153510; NP_001153511; NP_001153512; NP_663493
	Wikidata
View/Edit Human	View/Edit Mouse

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) is an enzyme that in humans is encoded by the NDUFS1 gene. The encoded protein, NDUFS1, is the largest subunit of complex I, located on the inner mitochondrial membrane, and is important for mitochondrial oxidative phosphorylation. Mutations in this gene are associated with complex I deficiency.