NDUFS2

NDUFS2
Identifiers
Aliases	NDUFS2, CI-49, NADH:ubiquinone oxidoreductase core subunit S2, MC1DN6
External IDs	OMIM: 602985; MGI: 2385112; HomoloGene: 56659; GeneCards: NDUFS2; OMA:NDUFS2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,214,395 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,078,957 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; left ventricle; ; mucosa of transverse colon; ; right adrenal gland; ; right adrenal cortex; ; right ventricle; ; right auricle of heart; ; myocardium of left ventricle; ; muscle of thigh;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; extensor digitorum longus muscle; ; interventricular septum; ; extraocular muscle; ; plantaris muscle; ; thoracic diaphragm; ; soleus muscle; ; digastric muscle; ; tibialis anterior muscle; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on NAD(P)H; 4 iron, 4 sulfur cluster binding; quinone binding; NADH dehydrogenase (ubiquinone) activity; iron-sulfur cluster binding; NAD binding; metal ion binding; protein binding; electron transfer activity; oxidoreductase activity; ubiquitin protein ligase binding; NADH dehydrogenase activity;
Cellular component	membrane; mitochondrial respiratory chain complex I; nucleoplasm; mitochondrial matrix; mitochondrion; mitochondrial inner membrane; respirasome;
Biological process	response to oxidative stress; mitochondrial respiratory chain complex I assembly; mitochondrial electron transport, NADH to ubiquinone; mitochondrial ATP synthesis coupled electron transport;
	Sources:Amigo / QuickGO
Orthologs
	4720
	226646
	ENSG00000158864
	ENSMUSG00000013593
	O75306
	Q91WD5
	NM_001166159; NM_004550
	NM_153064
NP_001159631; NP_004541; NP_001364227; NP_001364228; NP_001364229;
	NP_001364230; NP_001364231
	NP_694704
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (NDUFS2) also known as NADH-ubiquinone oxidoreductase 49 kDa subunit is an enzyme that in humans is encoded by the NDUFS2 gene. The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mutations in this gene are associated with mitochondrial complex I deficiency.