NDUFS8

NDUFS8
Identifiers
Aliases	NDUFS8, CI-23k, CI23KD, TYKY, NADH:ubiquinone oxidoreductase core subunit S8, MC1DN2
External IDs	OMIM: 602141; MGI: 2385079; HomoloGene: 1867; GeneCards: NDUFS8; OMA:NDUFS8 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,036,644 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,962,774 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; muscle of thigh; ; right auricle of heart; ; left ventricle; ; gastrocnemius muscle; ; mucosa of transverse colon;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; cardiac muscles; ; extraocular muscle; ; soleus muscle; ; intercostal muscle; ; medial vestibular nucleus; ; olfactory epithelium; ; deep cerebellar nuclei; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on NAD(P)H; NADH dehydrogenase (ubiquinone) activity; 4 iron, 4 sulfur cluster binding; oxidoreductase activity; iron-sulfur cluster binding; metal ion binding; NADH dehydrogenase activity;
Cellular component	mitochondrial respiratory chain complex I; mitochondrial matrix; respirasome; mitochondrion; membrane;
Biological process	response to oxidative stress; mitochondrial respiratory chain complex I assembly; mitochondrial electron transport, NADH to ubiquinone; aerobic respiration;
	Sources:Amigo / QuickGO
Orthologs
	4728
	225887
	ENSG00000110717
	ENSMUSG00000059734
	O00217
	Q8K3J1
	NM_002496
	NM_001271443; NM_001271444; NM_144870
	NP_002487
	NP_001258372; NP_001258373; NP_659119
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial also known as NADH-ubiquinone oxidoreductase 23 kDa subunit, Complex I-23kD (CI-23kD), or TYKY subunit is an enzyme that in humans is encoded by the NDUFS8 gene. The NDUFS8 protein is a subunit of NADH dehydrogenase (ubiquinone) also known as Complex I, which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Mutations in this gene have been associated with Leigh syndrome.