NEDD8

NEDD8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O
Identifiers
Aliases	NEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier
External IDs	OMIM: 603171; MGI: 97301; HomoloGene: 4485; GeneCards: NEDD8; OMA:NEDD8 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,232,367 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,909,581 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; superior frontal gyrus; ; right frontal lobe; ; anterior cingulate cortex; ; dorsolateral prefrontal cortex; ; nucleus accumbens; ; primary visual cortex; ; apex of heart; ; Hypothalamus; ; caudate nucleus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; somite; ; neural layer of retina; ; blastocyst; ; morula; ; superior frontal gyrus; ; embryo; ; maxillary prominence; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; protein tag;
Cellular component	cytosol; extracellular exosome; nucleus; nucleoplasm; cytoplasm;
Biological process	protein localization; anatomical structure morphogenesis; transforming growth factor beta receptor signaling pathway; response to organic cyclic compound; ubiquitin-dependent protein catabolic process; proteolysis; protein neddylation; protein deubiquitination; cellular iron ion homeostasis; protein ubiquitination; post-translational protein modification; modification-dependent protein catabolic process; regulation of proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	4738
	18002
	ENSG00000129559; ENSG00000285246
	ENSMUSG00000010376
	Q15843
	P29595
	NM_006156
	NM_008683
	NP_006147
	NP_032709
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The primary known substrates of NEDD8 modification are the cullin subunits of cullin-based E3 ubiquitin ligases, which are active only when NEDDylated. Their NEDDylation is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.