NEIL1

NEIL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TDH, 4NRV, 5ITY, 5ITQ, 5ITU, 5ITX, 5ITR, 5ITT
Identifiers
Aliases	NEIL1, FPG1, NEI1, hFPG1, nei like DNA glycosylase 1
External IDs	OMIM: 608844; MGI: 1920024; HomoloGene: 11616; GeneCards: NEIL1; OMA:NEIL1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	75,357,115 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,055,589 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; right adrenal cortex; ; right frontal lobe; ; minor salivary glands; ; left adrenal cortex; ; canal of the cervix; ; right lobe of liver; ; right lobe of thyroid gland; ; anterior pituitary;
	Top expressed in
	mesenteric lymph nodes; ; thymus; ; submandibular gland; ; otolith organ; ; utricle; ; brown adipose tissue; ; hand; ; right kidney; ; proximal tubule; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; hydrolase activity, hydrolyzing N-glycosyl compounds; hydrolase activity, acting on glycosyl bonds; damaged DNA binding; protein C-terminus binding; catalytic activity; lyase activity; nucleic acid binding; hydrolase activity; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity;
Cellular component	cytoplasm; chromosome; microtubule organizing center; cytoskeleton; nucleus; nucleoplasm;
Biological process	nucleotide-excision repair; response to oxidative stress; cellular response to DNA damage stimulus; depyrimidination; negative regulation of nuclease activity; metabolism; DNA repair; base-excision repair;
	Sources:Amigo / QuickGO
Orthologs
	79661
	72774
	ENSG00000140398
	ENSMUSG00000032298
	Q96FI4
	Q8K4Q6
	NM_001256552; NM_024608; NM_001352519; NM_001352520
	NM_028347; NM_001357409
	NP_001243481; NP_078884; NP_001339448; NP_001339449
	NP_082623; NP_001344338
	Wikidata
View/Edit Human	View/Edit Mouse

Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species (ROS) and introducing a DNA strand break via the associated lyase reaction.