NEIL2

NEIL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VZP
Identifiers
Aliases	NEIL2, NEH2, NEI2, nei like DNA glycosylase 2
External IDs	OMIM: 608933; MGI: 2686058; HomoloGene: 17032; GeneCards: NEIL2; OMA:NEIL2 - orthologs
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	63,431,305 bp
Gene ontology
Molecular function	DNA binding; microtubule binding; zinc ion binding; hydrolase activity, hydrolyzing N-glycosyl compounds; metal ion binding; hydrolase activity, acting on glycosyl bonds; damaged DNA binding; protein binding; catalytic activity; lyase activity; nucleic acid binding; DNA-(apurinic or apyrimidinic site) endonuclease activity; hydrolase activity; DNA N-glycosylase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity;
Cellular component	cytoplasm; microtubule cytoskeleton; spindle microtubule; nucleus; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	nucleotide-excision repair; cellular response to DNA damage stimulus; depyrimidination; metabolism; base-excision repair; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	252969
	382913
	ENSG00000154328
	ENSMUSG00000035121
	Q969S2
	Q6R2P8
	NM_001135746; NM_001135747; NM_001135748; NM_145043
	NM_201610
NP_001129218; NP_001129219; NP_001129220; NP_659480; NP_001336368;
	NP_001336369; NP_001336370; NP_001336371
	NP_963904
	Wikidata
View/Edit Human	View/Edit Mouse

Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM]