NIMA-related kinase 1

NEK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4APC, 4B9D
Identifiers
Aliases	NEK1, NY-REN-55, SRPS2, SRPS2A, SRTD6, NIMA related kinase 1, ALS24
External IDs	OMIM: 604588; MGI: 97303; HomoloGene: 14376; GeneCards: NEK1; OMA:NEK1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	169,612,632 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	61,584,380 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; trigeminal ganglion; ; spinal ganglia; ; optic nerve; ; sural nerve; ; internal globus pallidus; ; sperm; ; pars reticulata; ; pars compacta; ; lactiferous duct;
	Top expressed in
	sciatic nerve; ; zygote; ; secondary oocyte; ; vestibular sensory epithelium; ; trigeminal ganglion; ; facial motor nucleus; ; cumulus cell; ; lumbar spinal ganglion; ; iris; ; ciliary body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity; 14-3-3 protein binding;
Cellular component	cytoplasm; centrosome; pericentriolar material; microtubule organizing center; cytoskeleton; nucleus;
Biological process	phosphorylation; cell division; protein phosphorylation; cell projection organization; cell cycle; peptidyl-tyrosine phosphorylation; cilium assembly; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	4750
	18004
	ENSG00000137601
	ENSMUSG00000031644
	Q96PY6
	P51954
NM_001199397; NM_001199398; NM_001199399; NM_001199400; NM_012224;
	NM_001374418; NM_001374419; NM_001374420; NM_001374421; NM_001374422; NM_001374423
	NM_001293637; NM_001293638; NM_001293639; NM_175089
NP_001186326; NP_001186327; NP_001186328; NP_001186329; NP_036356;
	NP_001361347; NP_001361348; NP_001361349; NP_001361350; NP_001361351; NP_001361352
	NP_001280566; NP_001280567; NP_001280568; NP_780298
	Wikidata
View/Edit Human	View/Edit Mouse

NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation; defects in this gene can be a cause of polycystic kidney disease. NEK1 is thought to be involved in amytrophic lateral sclerosis.

The gene was discovered by researchers with Project MinE, with the ALS Association providing funding raised through the Ice Bucket Challenge.