NEK3

NEK3
Identifiers
AliasesNEK3, HSPK36, NIMA related kinase 3
External IDsOMIM: 604044; MGI: 1344371; HomoloGene: 1869; GeneCards: NEK3; OMA:NEK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4752

23954

Ensembl

ENSG00000136098

ENSMUSG00000031478

UniProt

P51956

Q9R0A5

RefSeq (mRNA)

NM_001146099
NM_002498
NM_152720

NM_001162947
NM_011848

RefSeq (protein)

NP_001139571
NP_002489
NP_689933

NP_001156419
NP_035978

Location (UCSC)Chr 13: 52.13 – 52.16 MbChr 8: 22.62 – 22.66 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene.

In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.