NELL2

NELL2
Identifiers
Aliases	NELL2, NRP2, neural EGFL like 2
External IDs	OMIM: 602320; MGI: 1858510; HomoloGene: 4488; GeneCards: NELL2; OMA:NELL2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	44,921,848 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	95,426,440 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; retinal pigment epithelium; ; orbitofrontal cortex; ; frontal pole; ; superior frontal gyrus; ; endothelial cell; ; Brodmann area 10; ; germinal epithelium; ; postcentral gyrus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; medial dorsal nucleus; ; CA3 field; ; perirhinal cortex; ; piriform cortex; ; entorhinal cortex; ; Region I of hippocampus proper; ; medial geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; protein kinase C binding; heparin binding;
Cellular component	extracellular region; cytoplasm;
Biological process	neuron cellular homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	4753
	54003
	ENSG00000184613
	ENSMUSG00000022454
	Q99435
	Q61220
	NM_001145107; NM_001145108; NM_001145109; NM_001145110; NM_006159
	NM_001289653; NM_016743; NM_001356950; NM_001356951
	NP_001138579; NP_001138580; NP_001138581; NP_001138582; NP_006150
	NP_001276582; NP_001343879; NP_001343880
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C-binding protein NELL2 is an enzyme that in humans is encoded by the NELL2 gene.

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full length sequence has not been determined.