NFAT5

NFAT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IMH
Identifiers
Aliases	NFAT5, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP, nuclear factor of activated T-cells 5, tonicity-responsive, nuclear factor of activated T-cells 5, nuclear factor of activated T cells 5
External IDs	OMIM: 604708; MGI: 1859333; HomoloGene: 4811; GeneCards: NFAT5; OMA:NFAT5 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	69,704,666 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	108,106,149 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; nipple; ; caput epididymis; ; corpus epididymis; ; tail of epididymis; ; Achilles tendon; ; saphenous vein; ; epithelium of colon; ; lactiferous duct; ; vena cava;
	Top expressed in
	ascending aorta; ; aortic valve; ; gastrula; ; medullary collecting duct; ; adrenal gland; ; skin of external ear; ; trachea; ; habenula; ; vestibular membrane of cochlear duct; ; umbilical cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding; transcription factor binding;
Cellular component	nucleus; nucleoplasm; cytoplasm; cytosol; transcription regulator complex;
Biological process	regulation of calcineurin-NFAT signaling cascade; cytokine production; positive regulation of gene expression; excretion; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; signal transduction; positive regulation of transcription by RNA polymerase II; calcineurin-NFAT signaling cascade; response to osmotic stress; cellular response to cytokine stimulus; positive regulation of NIK/NF-kappaB signaling; positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
Orthologs
	10725
	54446
	ENSG00000102908
	ENSMUSG00000003847
	O94916
	Q9WV30
NM_001113178; NM_006599; NM_138713; NM_138714; NM_173214;
	NM_173215; NM_001367709
	NM_001286260; NM_018823; NM_133957
NP_001106649; NP_006590; NP_619727; NP_619728; NP_775321;
	NP_775322; NP_001354638
	NP_001273189; NP_061293; NP_598718
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor of activated T-cells 5, also known as NFAT5 and sometimes TonEBP, is a human gene that encodes a transcription factor that regulates the expression of genes involved in the osmotic stress.

The product of this gene is a member of the nuclear factors of activated T cells (NFAT) family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.