NFE2

NFE2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KZ5
Identifiers
Aliases	NFE2, NF-E2, p45, nuclear factor, erythroid 2
External IDs	OMIM: 601490; MGI: 97308; HomoloGene: 4491; GeneCards: NFE2; OMA:NFE2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,301,015 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,166,830 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; trabecular bone; ; bone marrow; ; bone marrow cells; ; spleen; ; testicle; ; right lung; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; fetal liver hematopoietic progenitor cell; ; tibiofemoral joint; ; blood; ; spleen; ; human fetus; ; yolk sac; ; embryo; ; bone marrow; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; transcription coactivator activity; transcription cis-regulatory region binding; protein binding; WW domain binding; DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; PML body; nucleus; nucleoplasm; protein-DNA complex;
Biological process	hemostasis; regulation of transcription, DNA-templated; blood coagulation; blood circulation; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; nucleosome disassembly; regulation of transcription by RNA polymerase II; regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4778
	18022
	ENSG00000123405
	ENSMUSG00000058794
	Q16621
	Q07279
NM_001136023; NM_001261461; NM_006163; NM_001400365; NM_001400372;
	NM_001400373
NM_008685; NM_001302338; NM_001302339; NM_001302340; NM_001302341;
	NM_001302343; NM_001400376
	NP_001129495; NP_001248390; NP_006154
NP_001289267; NP_001289268; NP_001289269; NP_001289270; NP_001289272;
	NP_032711; NP_001387305
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.

It is involved in megakaryocyte production.