NFX1

NFX1
Identifiers
Aliases	NFX1, NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1
External IDs	OMIM: 603255; MGI: 1921414; HomoloGene: 1875; GeneCards: NFX1; OMA:NFX1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,371,157 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,025,993 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; skin of hip; ; tail of epididymis; ; caput epididymis; ; corpus epididymis; ; endothelial cell; ; right ventricle; ; oral cavity; ; skin of thigh; ; biceps brachii;
	Top expressed in
	cumulus cell; ; primitive streak; ; epiblast; ; gastrula; ; seminal vesicula; ; dermis; ; neural layer of retina; ; hair follicle; ; superior frontal gyrus; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; zinc ion binding; ligase activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; metal ion binding; nucleic acid binding; RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transferase activity; ubiquitin protein ligase activity;
Cellular component	plasma membrane; nucleolus; nucleus; cytosol;
Biological process	inflammatory response; viral process; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of MHC class II biosynthetic process; transcription, DNA-templated; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	4799
	74164
	ENSG00000086102
	ENSMUSG00000028423
	Q12986
	B1AY10
	NM_002504; NM_147133; NM_147134; NM_001318758
	NM_001290448; NM_001290449; NM_023739
	NP_001305687; NP_002495; NP_667345
	NP_001277377; NP_001277378; NP_076228
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.