Sodium-hydrogen exchange regulatory cofactor 2

SLC9A3R2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D11, 2HE4, 2OCS, 4P0C
Identifiers
Aliases	SLC9A3R2, E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1, Sodium-hydrogen exchange regulatory cofactor 2, SLC9A3 regulator 2
External IDs	OMIM: 606553; MGI: 1890662; HomoloGene: 56962; GeneCards: SLC9A3R2; OMA:SLC9A3R2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,039,026 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,869,301 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lung; ; right lobe of liver; ; upper lobe of left lung; ; right lobe of thyroid gland; ; right auricle of heart; ; right coronary artery; ; left lobe of thyroid gland; ; left uterine tube; ; left coronary artery;
	Top expressed in
	external carotid artery; ; aortic valve; ; motor neuron; ; internal carotid artery; ; ascending aorta; ; right lung; ; right lung lobe; ; carotid body; ; left lung; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular adaptor activity; phosphatase binding; beta-catenin binding; signaling receptor binding; protein C-terminus binding; protein binding; cadherin binding;
Cellular component	plasma membrane; extracellular exosome; apical plasma membrane; membrane; endomembrane system; nucleus; focal adhesion;
Biological process	protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	9351
	65962
	ENSG00000065054
	ENSMUSG00000002504
	Q15599
	Q9JHL1
	NM_001130012; NM_001252073; NM_001252075; NM_001252076; NM_004785
	NM_023055; NM_023449; NM_001357796
	NP_001123484; NP_001239002; NP_001239004; NP_001239005; NP_004776
	NP_075542; NP_075938; NP_001344725
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 (solute carrier family 9 isoform A3 regulatory factor 2) gene.

NHERF-2 is a scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. It is necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. In addition, it may also act as scaffold protein in the nucleus.