CD244

CD244
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z2K, 2PTT, 2PTU
Identifiers
Aliases	CD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 molecule
External IDs	OMIM: 605554; MGI: 109294; HomoloGene: 9493; GeneCards: CD244; OMA:CD244 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,862,887 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,437,314 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; testicle; ; spleen; ; bone marrow; ; bone marrow cells; ; lymph node; ; appendix; ; right lobe of liver;
	Top expressed in
	granulocyte; ; blood; ; spleen; ; Paneth cell; ; pharynx; ; bone marrow; ; decidua; ; duodenum; ; jejunum; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC class I protein binding; protein binding; signaling receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane; external side of plasma membrane;
Biological process	innate immune response; positive regulation of granzyme B production; immune system process; leukocyte migration; adaptive immune response; signal transduction; positive regulation of inositol phosphate biosynthetic process; immune response; natural killer cell activation involved in immune response;
	Sources:Amigo / QuickGO
Orthologs
	51744
	18106
	ENSG00000122223
	ENSMUSG00000004709
	Q9BZW8
	Q07763
	NM_001166663; NM_001166664; NM_016382
	NM_018729
	NP_001160135; NP_001160136; NP_057466
	NP_061199
	Wikidata
View/Edit Human	View/Edit Mouse

CD244 (Cluster of Differentiation 244) also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene.

CD244 is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule family of receptors (SLAMF) which are expressed in different types of hematopoietic cells. CD244 plays a role in the regulation of the immune system.

A ligand of CD244 is CD48 (SLAMF2). CD48 also belongs to the SLAMF, it does not have an intracellular domain and it is anchored to the plasma membrane by a GPI-anchor. Only these two receptors from the SLAMF mediate heterophilic interactions.