NKRF (gene)

NKRF
Identifiers
Aliases	NKRF, ITBA4, NRF, NFKB repressing factor
External IDs	OMIM: 300440; MGI: 1924536; HomoloGene: 84816; GeneCards: NKRF; OMA:NKRF - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	119,606,443 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	36,167,166 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; Brodmann area 23; ; superior frontal gyrus; ; middle temporal gyrus; ; gonad; ; entorhinal cortex; ; primary visual cortex; ; Brodmann area 46; ; Pons; ; prefrontal cortex;
	Top expressed in
	pontine nuclei; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; primitive streak; ; facial motor nucleus; ; deep cerebellar nuclei; ; spinal cord; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; nucleic acid binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleolus; nucleoplasm;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	55922
	77286
	ENSG00000186416
	ENSMUSG00000044149
	O15226
	Q8BY02
	NM_001173487; NM_001173488; NM_017544
	NM_029891
	NP_060014
	NP_084167
	Wikidata
View/Edit Human	View/Edit Mouse

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes.

The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.